Cytology. Since the publication of the consensus guidelines, new cervical cancer screening guidelines have been published and new information has. ASCCP Guideline. HPV Unknown. HPV Positive*. Repeat Cytology. -. @ 12 mos. Cytology. @ 6 & 12 mos OR. HPV DNA Testing. @ 12 mos. ASC or HPV (+) —. Manage per. ASCCP Guideline. HPV Unknown. HPV Positive*. Repeat cytology. >> ASC or HPV (+) > Repeat Colposcopy. @ 12 mos cytology. @6& 12 mos OR.

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Why new guidelines now? Immediate treatment is an option for adult women but not for adolescents with high-grade squamous intraepithelial lesion. Genital human papillomavirus infection: Choose a single article, issue, or full-access subscription.

If CIN 2,3 is ascpc found, cytology and colposcopy are preferred every six months for one year with biopsy if high-grade lesions are identified or if HSIL persists on subsequent cytology. HPV genotyping tests are now available. Colposcopy is also recommended when two consecutive Paps are unsatisfactory. HPV positivity has a high positive predictive value for significant cervical disease, with 20 percent of women having CIN 3 or cancer on biopsy.

If satisfactory colposcopy does not identify CIN 2,3 and endocervical sampling is negative, management may include a diagnostic assccp procedure or cytology and colposcopy every six months until both are negative twice.

Consensus Guidelines FAQs – ASCCP

Guidelines were developed by 1 conventional literature review and evidence weighting, and 2 risk-based assessment algrithm various management strategies using observational data from KPNC. Draft guidelines were created, published online for public comment, revised as needed and presented at a consensus conference in Bethesda, MD, Sept High-grade squamous intraepithelial lesion.


Adenocarcinoma in situ of the cervix: Human papillomavirus DNA detection and histological asxcp in women referred for atypical glandular cells or adenocarcinoma in situ in their Pap smears. When CIN3 is found in women of any age, treatment is recommended.

Updated Consensus Guidelines FAQs

Apgar is a member of the American Society for Colposcopy and Cervical Pathology Board of Directors and author of two colposcopy publications. Randomized controlled trial of human papillomavirus testing versus Pap cytology in the primary screening for cervical cancer precursors: Management of women with low-grade squamous intraepithelial lesion.

Colposcopy is recommended for adult women with low-grade squamous intraepithelial lesion LSIL aglorithm, because 28 percent will harbor CIN 2,3 over a two-year period 5623 Figure 3 6. References 5 through 8 are American Society for Colposcopy and Cervical Pathology consensus guidelines, expert review.

Evaluating the endocervical canal for neoplasia by colposcopy or endocervical sampling. More in Pubmed Citation Related Articles.

Prospective follow-up suggests similar risk of subsequent cervical zlgorithm neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy.

Screening for high-grade cervical intraepithelial neoplasia and cancer by testing for high-risk HPV, routine cytology or colposcopy. Now, providers who use cotesting will be receiving combinations of results, some of which will be discordant e. Int J Gynecol Pathol. Prevalence of cervical intraepithelial neoplasia in sexually active teenagers and young adults. If algorihm indicates CIN 2,3—not otherwise specified, adolescents may undergo colposcopy and cytology every six months up to 24 months, or treatment with excision or ablation.

J Low Genit Tract Dis. Management algorithms and information on strength of recommendations and quality of evidence can be found at http: What alyorithm I do? Clinical judgement is always appropriate. When CIN2 alhorithm found in young women, observation is preferred but treatment is acceptable.


These low-risk women are at high risk for HPV exposure and lesions, and should be observed. Providers need guidance on how to manage women with discordant results.

Immediate access to this article. See related handout on HPV and Pap testingwritten by the authors of this article.

ASCCP Mobile App – ASCCP

N Algoirthm J Med. Because the KPNC follow up of patients covers less than 10 years, more time will be needed to see if these women can return to routine screening after multiple negative follow-up tests.

Women with no CIN2,3 at colposcopy should be observed with colposcopy and cytology every 6 months for up to two years, until 2 consecutive negative Pap tests are reported and no high-grade colposcopic abnormality is observed. Atypical squamous cells—cannot exclude HSIL. Read the full article.

Human papillomavirus testing is now included for management of atypical glandular cytology, for follow-up after treatment for cervical intraepithelial neoplasia, and algorihtm combination with cytologic screening in women 30 years and older.

Address correspondence to Barbara S. Treatment during pregnancy is unacceptable unless invasive carcinoma is identified. Algorithms are available at www. Obtaining a histologic specimen of the transformation zone and endocervical canal by laser or cold-knife conization or loop electrosurgical excision or conization. Biopsy correlates of abnormal cervical cytology classified using the Bethesda system. Low-grade alglrithm intraepithelial lesion.