INFeD® improved the hemoglobin response to erythropoietic therapy in patients with documented INFeD® full Prescribing Information. Watson Pharma, Inc. 1 mL of INFeD provides 50 mg of elemental iron UpToDate (courtesy of Lexicomp), or the prescribing information. INFeD: INFeD is administered by intramuscular or intravenous injection. Before . during the acute phase of infectious renal disease (manufacturer’s information) . Therefore, the therapeutic prescription use of iron is usually compatible with.
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Potential alternatives include iron salts, polysaccharide-iron complex, and iron sucrose.
Iron dextran (INFeD)
Total Dose Intravenous Infusion : The contribution of iron to infectious processes knfed unclear, but iron dextran should not be administered during the acute phase of infectious renal disease manufacturer’s information. Deferoxamine is indicated ibfed a treatment of iron toxicity or overdose.
Following intramuscular injection of iron dextran, the drug is slowly absorbed in two stages primarily through the lymphatic system. Serious anaphylactoid reactions require appropriate resuscitative measures. If test dose uneventful, infuse the remainder of the total calculated dose IV over 2 to 6 hours.
If test dose uneventful, give the remainder of the total dose as mg elemental iron per day IM or IV until the total calculated dose is given. However, trace amounts of unmetabolized iron dextran are excreted in breast milk. Parenteral iron preparations e. The liver is one of the prescribingg storage sites for iron, and advanced chronic liver disease may result in excess storage prescribihg in the liver. Because anaphylactic reactions are known to occur after uneventful test doses, subsequent test doses should be considered.
Once the infusion is completed, flush vein with NS injection. Therapeutically, it is typically illogical for a patient to receive both iron supplementation e.
U.S. Prescribing Information Disclaimer
Do not add therapeutic doses of iron dextran to total parenteral nutrition TPN solutions; iron dextran may destabilize the mixture or cause the cracking of the TPN emulsion. Major Deferasirox chelates iron and is indicated as a treatment of iron toxicity or overdose. Use of iron dextran in infants younger than 4 months of age and neonates is not recommended; there have been reports from other countries of an increased incidence of gram-negative sepsis e.
Severe Deferoxamine chelates iron from ferritin or hemosiderin. A value of 12 may be used as a target normal hemoglobin.
Normal erythropoiesis is dependent on the concentration of iron and erythropoietin available in the plasma. Safety and efficacy have not been established. Adults, Adolescents, and Presfribing weighing more than 15 kg. If test dose uneventful, give the remainder of the total dose as pescribing mg of elemental iron per day IM or slow IV until the total calculated dose needed given. DexFerrum is administered by intravenous prescribnig only. If necessary, iron may be given in short courses, but since iron and trientine each inhibit oral absorption of the other, 2 hours should elapse between administration of trientine and iron doses.
Serum iron, hemoglobin and hematocrit should be evaluated prior to infdd therapy and at regular intervals during therapy. Furthermore, concomitant use of angiotensin-converting enzyme inhibitors may increase the risk for serious reactions to iron dextran. Dilute the total calculated dose see Dosage in to mL of 0. To avoid staining of subcutaneous tissue, use the Z-track technique of injection. Anemia, hemochromatosis, hemoglobinopathy, hemosiderosis.
See individual dosage if using total dose IV infusion methods. Total dosage with iron dextran must be individualized according to the patients age, weight, and the degree of the iron-deficiency anemia.
Both animal and human data indicate that the bulk of intravenous iron is sequestered in the reticuloendothelial system i. Adults, Adolescents, and Children weighing 10 kg or more. Patients with hepatic disease should receive iron dextran with caution. The use of infrmation dextran to prevent iron deficiency in patients requiring long-term parenteral nutrition support is controversial; some experts advocate the use of iron to treat a deficiency if it occurs vs.
Your Name Your name is required. Hemosiderosis secondary to long-term iron dextran treatment has primarily been reported in patients with renal failure receiving dialysis. Because anaphylactic reactions are known to occur after uneventful test doses, test doses before subsequent doses should be considered. Infants and Children 4 months and older weighing less than 15 kg.
Iron crosses the placenta, and pregnancy increases iron-intake requirements. There are limits to the volume of iron dextran that may be injected IV undiluted per 24 hours based on patient age and weight; see dosage guidelines.
Intramuscular infomation Intravenous dosage.
INFeD (iron dextran) dose, indications, adverse effects, interactions from
knformation Ferric iron is then gradually released into the plasma where it combines rapidly with transferrin. Transferrin delivers iron to specific receptors for deposit, where it is either incorporated into hemoglobin or oxidized and stored in combination with apoferritin as ferritin. Moderate The concomitant use of angiotensin-converting enzyme inhibitors ACE inhibitors with iron dextran may increase the risk for anaphylactic-type reactions.