The Kurnakov test, also known as Kurnakov’s reaction, is a chemical test that The test was devised by Soviet chemist Nikolai Semenovich Kurnakov. I’m trying to answer this question: However, I don’t fully understand the exact synthesis of the thiourea complexes. For one, I don’t understand. of substituted pyrimidines and their products from thiourea in Kurnakov’s reaction react with thiourea (tu) to give different products (Kurnakov’s test).

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Adequate hydration and diuresis is used to prevent renal damage. This page was last edited on 25 Aprilat Following Stalins death ina period of political and kurnamov liberalization, known as de-Stalinization and Khrushchevs Thaw, the country developed rapidly, as millions of peasants were moved into industrialized cities.

Ann Chemie Pharm ; His father Nikolay Nikanorovich Dobrokhotov was a telegraphist. In other projects Wikimedia Commons.

In the last decade of his life he helped to establish the nuclear fuel industry in the U. Senior staff scientist on specialty inorganic chemistrydoctor of chemical sciencesprofessorcorresponding member of the ASacademici Canadian Journal of Chemistry. His mother — Maria Fedorovna Vladimirskaya, graduate of Smolny Institute — was from the Vladimirskie family, many of whose members were engaged in social activities maternal uncle — Mikhail Fyodorovich Vladimirsky — one of the oldest figures of the communist party, companion in arms of Vladimir Leninwere friends of Maxim Gorky.

In his later years, he focused his work on platinum chemistry and platinum production. The dose is reduced when the patient’s creatinine clearance a measure of renal function is reduced. The Secret Agent’s Blunder Russian: The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species.

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During a trip to France, Germany and Austria Kurnakov studied salt manufacturing in several locations. Journal of Chemical Education. The nephrotoxicity of platinum-class drugs seems to be related to reactive oxygen species and in animal models can be ameliorated by free radical scavenging agents.

Stretching by as much as 0. Trans effect — In inorganic chemistry, the trans effect is the labilization of ligands that are trans to certain other ligands, which can thus be regarded as trans-directing ligands.

Uses authors parameter link. Interaction with cellular proteins, particularly HMG domain proteins, has also been advanced as a mechanism of interfering with mitosis, although this is probably not its primary method of action.

Kurnakov Test on [Pt

InKurnakov became professor of inorganic chemistry for his work on the reactions of cis- and trans- platinum complexes with thioureatoday known as the Kurnakov test. Nauk, 169; L. Kurnakov was born in NolinskKirov Oblast.

Transplatin, the trans diastereomer of cisplatin, has formula trans -[PtCl 2 NH 3 2 ] and does not exhibit a comparably useful pharmacological effect.

This contains a bibliography of one hundred and one titles to early Uses authors parameter link. As such, his name is associated with a new and advanced method for the purification of platinum, its separation in highest purity, the preparation of pure osmium, a method for extracting platinum metals from low grade tesy, the development of a series of analytical methods for noble metals, and the solution of tesh other critical industrial problems.

Inhe graduated with honours from Moscow D.

Kurnakov test | Revolvy

Cis 1,2 dichlorocyclohexane 2D skeletal. The trans compound gives a colourless solution from which snow white needles of trans-[Pt tu 2 Cl 2 ] deposit on cooling. Note that although cisplatin is frequently designated as an alkylating agent, it has no alkyl group and cannot carry out alkylating reactions. In a procedure by Woollins et al.


Inhe entered to the post graduate courses in I. The Kurnakov test is sometimes used to detect transplatin in samples of the drug cisplatin. Member feedback about Kurnakov test: As a kurnakof, the country underwent a period of rapid industrialization and collectivization which laid the foundation for its victory in World War II and postwar dominance of Eastern Europe. It was the first member of its class, which now also includes carboplatin and oxaliplatin.

Trans 1,2 dichlorocyclohexane 2D skeletal. Benjamin, New York,p. He published his first paper on alum crystallization and sodium thioantimoniate in Canadian Journal of Chemistry.

Nikolai Semenovich Kurnakov

The goal was to preserve the Communist Party while reversing the economic stagnation, the Cold War ended during his tenure, and in Soviet satellite countries in Eastern Europe overthrew their respective communist regimes.

A mineral was named kurakov in his honor. Retrieved from ” https: Most notable among the DNA changes are the 1,2-intrastrand cross-links with purine bases.

Among the subjects included in kurna,ov more than articles are the synthesis, reactions, structure-proof, thermochemistry, thermodynamics, photochemistry, spectroscopy, and optical properties of complexes of the platinum metals. He was also awarded a Doctor honoris causa by University of Moscow in